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Current treatment for hair loss


Registered on 2018. 07. 03

Pattern of hair loss (androgenic alopecia)

Pattern of hair loss is hair loss that primarily affects the top and front of the scalp. In males, the hair loss often presents as a receding hairline while in females it typically presents as a thinning of the hair. Male pattern hair loss is due to a combination of genetics and the male hormone dihydrotestosterone. The cause in female pattern hair loss remains unclear. Pattern hair loss by the age of 50 affects about half of males and a quarter of females. It is the most common cause of hair loss.


Causes of hair loss

Although hair follicles were previously thought to be permanently gone in areas of complete hair loss, they are more likely dormant, as recent studies have shown the scalp contains the stem cell progenitor cells from which the follicles arose. With increasing age, androgens stimulate hair growth on the face, but can suppress it at the temples and scalp vertex, a condition that has been referred to as the 'androgen paradox'.


Some common treatments for hair loss

Minoxidil

Minoxidil is an antihypertensive vasodilator medication and is used to treat hair loss. It is available as a generic medication and over the counter for the treatment of androgenic alopecia. Minoxidil, applied topically, is widely used for the treatment of hair loss. It is effective in helping promote hair growth in both men and women with androgenic alopecia. About 40% of men experience hair regrowth after 3–6 months. Minoxidil must be used indefinitely for continued support of existing hair follicles and the maintenance of any experienced hair regrowth. Minoxidil is generally well tolerated, but common side effects include burning or irritation of the eye, itching, redness or irritation at the treated area, and unwanted hair growth elsewhere on the body.


RU-58841 (also known as PSK-3841 or HMR-3841)

RU-58841 is a nonsteroidal antiandrogen (NSAA). RU58841 differs from other anti-androgens in that rather than trying to reduce or block the production of testosterone or DHT, it focuses on the testosterone receptor. As RU58841 does not affect the production of either testosterone or DHT, the patient’s hormone levels are unchanged. As long as the treatment is localized to the area it is needed, there shouldn’t be any unwanted side-effects. RU-58841 is specifically designed as a topical treatment. Topical RU58841 has a very short half-life (1 hr) in comparison to the oral ingestion of Finasteride (6 hrs) and Dutasteride (5 weeks). Moreover, RU58841 does not inhibit DHT production like the latter two products. These facts seem to suggest that there is minimal chance of any serious or permanent side effects, and anecdotal evidence on the forums seems to support that. RU58841 has established itself as a powerful treatment besides the likes of finasteride and dutasteride.


Finasteride and Dutasteride

A number of publications with high levels of evidence support the safety of finasteride and dutasteride in men and women with androgenic alopecia. Common side effects include low risk of adverse sexual effects (very similar to placebo) and an increase in the risk of cancer.


Regenerative medicine therapies and stem hair cell growth

There are 2 types of stem cell treatment: E1, which involves hair cloning by the injection of follicular stem cells previously expanded in vitro, producing the growth of new follicles; and E2, adipose-derived, stem cells. Recent data suggest that by influencing hair follicle stem cells could be a novel and powerful to promote hair growth. The first drug, called RCGD423, activates a cellular signaling pathway called JAK-Stat, which transmits information from outside the cell to the nucleus of the cell. The research showed that JAK-Stat activation leads to the increased production of lactate and this in turn drives hair follicle stem cell activation and quicker hair growth. Animal treated with RCGD423 show pigmentation and hair growth, after 5 doses. The other drug, called UK5099, blocks pyruvate from entering the mitochondria, which forces the production of lactate in the hair follicle stem cells and accelerates hair growth in mice. Animal treated topically with UK-5099, twice daily, show pigmentation and hair growth, after 8 days of treatment; full anagen, indicated by a full coat of hair, is achieved after 14 days of treatment


List of Articles

Current treatment for hair loss

  • Jul 03, 2018

Pattern of hair loss (androgenic alopecia) Pattern of hair loss is hair loss that primarily affects the top and front of the scalp. In males, the hair loss often presents as a receding hairline while in females it typically presents as a thinning of the hair. Male pattern hair loss is due to a combination of genetics and the male hormone dihydrotestosterone. The cause in female pattern hair loss remains unclear. Pattern hair loss by the age of 50 affects about half of males and a quarter of...
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PREBIOTICS versus PROBIOTICS

  • Jul 03, 2018

While PREBIOTICS and PROBIOTICS sound similar, these supplements are very different and have different roles in the skin diverse microbiota community. PREBIOTIC FIBER is a non-digestible part of foods like bananas, onions and garlic, Jerusalem artichoke, the skin of apples, chicory root, beans, and many others. Prebiotic fiber goes through the small intestine undigested and is fermented when it reaches the large colon. This fermentation process feeds beneficial bacteria colonies (includin...
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Impact of Prebiotics and probiotics on skin health

  • Jul 03, 2018

The skin ecosystem is a complex environment covered with a diverse microbiota community. These are classified as either transient or resident, where some are considered as beneficial, some essentially neutral and others pathogenic or at least have the capacity to be pathogenic. Recent data suggest that prebiotics and probiotics influence skin health by modulating the cutaneous microbiota. Pre- and probiotic beneficial effects can be delivered topically or systemically (by ingestion). The pre- and ...
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Acne

  • Oct 15, 2012

What Causes Acne? From the moment you are born, your skin begins a lifelong process of shedding dead cells and producing oil. This process can be disrupted by your hormone balance, which changes throughout your life. The acne cycle is initiated when excess oil and dead skin cells combine to plug the pore of a hair follicle; behind the plugged pore, bacteria grow and multiply, triggering inflammation and swelling. That's an acne blemish. All types of acne - blackheads, whiteheads, pimples, and cysts - ...
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Skin Care for Wrinkle and Aging imagefile

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Background Aging comes along and brings baggage in the form of wrinkles. Some are not preventable while others are. Facial wrinkles appear without any warning. The most common reasons are aging, environmental damage, loss of moisture and impaired new cell growth. Repetitive movements of facial muscles such as frowning, squinting, and even smiling can drastically speed up the wrinkle process. There are 3 types of wrinkles. Anti-aging treatments, from holistic home prevention methods to clinical injections at a medical ...
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Skin Care for Acne-prone Skin

  • Oct 15, 2012

Proper skin care can be just as important as the treatment(s) you use to clear your acne. Proper skin care can reduce possible side effects from prescription medications. Proper skin care can even help you prevent new breakouts once your skin clears. - 7 Acne Skin Care Taboos - How to Wash Acne-prone Skin - How to Choose Makeup, Moisturizer, and Sunscreen - How to Protect Your Skin from the Sun - How to Shave if You Have Acne or Acne-prone Skin 7 Acne Skin Care Taboos D...
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